West Yorkshire Fire and Rescue Service were called to a building in Bretton Park Way, Savile Town just after 7pm on Monday.
Police are also in attendance and have cordoned off the road.
Eight pumps are currently at the scene.
A fire service spokesman said: "Crews are in attendance at a large fire at Bretton Park Way, Savile Town, Dewsbury.
"Due to the amount of smoke, residents in the local area are advised to keep windows and doors shut.
"Please avoid travelling through this area."