The girls Issy, 3, and Evie, 2, love being out and seeing the world, playing with their dolls and are keen learners.
The pair have been put up for adoption by Adopt South who say they were "not looked after as well as they could have been".
Hampshire adoption agency 'Adopt South' say they need to be adopted by a "permanent, loving and compassionate" family.
They are currently living with a very qualified and experienced foster carer who is used to looking after children in need of additional needs.
But the pair need somewhere final to settle down in and provide some security and care.
Adopt South says that as a result of her experiences, the eldest sister Issy can react in a way that seems younger than her age due to a delay in her development in her early years.
At times, she can feel “scared or confused as she cannot always work out what is the best thing to do".
Adopt South says that during these times she can become scared or confused, or even angry, but is calmed and comforted with care and cuddles.
Issy’s foster carer added: “Issy can be an adorable little girl, who has made amazing progress in the last year. She will spend hours talking and playing with her dolls, and pushing her pram around the house.
“Her favourite film is Disney’s Frozen. She needs a lot of comfort from a loving parent, or parents, who will have the time to soothe and help develop her confidence so she can flourish.”
Evie meanwhile is just at the stage of wanting to "explore everything" and enjoys spending time outside, playing with her foster parent's dogs and spending lots of time with other people who can read to and listen to her.
Adopt South says she also has difficulties expressing herself due to her early life experiences.
“Issy and Evie are lovely little girls who have been through experiences that most children their age would not have been exposed to, which makes them feel very vulnerable at times,” said Rachel Reynolds, head of Adopt South.
“The girls need a family life where their adoptive parent/s will have an understanding or experience working or caring for children with additional needs - or within a community or faith where they are fully supported with family and friendship groups around them.
“Issy and Evie need the time, commitment and love to develop into happy and confident girls. Adopt South is committed to supporting the girls and their adoptive parent/s throughout their childhood journey whenever they need it. We are here to help children like Issy and Evie thrive and be happy as they grow up.”
If you would like to know more about Issy and Evie, or about adoption, please call Adopt South on 0300 3000 011.