The result leaves Carlos Corberan's side lying perilously in 19th place, seven points above the relegation zone, and should Rotherham United pick up points from their two games in hand, Huddersfield could well become embroiled in a battle to avoid a bottom-three finish.
Speaking in the wake of the defeat, the Terriers boss said: "Football is not about how many chances you create it is about how many chances you take. We did not make the most of those chances.
“Preston used their opportunities well and they were much better than us in that area.”
Huddersfield will look to bounce back tomorrow night, when they take on fellow strugglers Birmingham City in a must-win game at the John Smith's Stadium.
The Terriers will be out for revenge following the two sides' last meeting, where a 90th minute Lukas Jutkiewic goal saw Birmingham snatch a late win at St. Andrew's.
Here are today's biggest transfer stories and the latest team news involving Huddersfield Town and the rest of the Championship, ahead of the midweek action:
1. Howe favourite for Celtic job
Ex-Bournemouth manager Eddie Howe is the fresh favourite for the Celtic job, as the Scottish Premiership champions eye up Neil Lennon's successor. Howe has been out of work since leaving the Cherries last August. (SkyBet) Photo: CLIVE BRUNSKILL
2. Rovers striker could cost £25m
Blackburn Rovers are set to demand a fee in the region of £25m for star striker Adam Armstrong this summer, mindful of fact his former club Newcastle will pocket 40% of the sell-on fee. He's a key target of West Ham United. (Daily Mail) Photo: Laurence Griffiths
3. Defoe tipped for Championship move
Ex-football Noel Whelan has claimed Rangers' Jermaine Defoe, 38, is still good enough to impress in the Championship, and would be a "massive signing" for any second-tier side able to sign him in the next transfer window. (Football Insider) Photo: Ian MacNicol
4. Keogh issues Huddersfield Town rallying cry
Following his side's seventh defeat in ten matches, Huddersfield Town defender Richard Keogh has urged his side to "stick together" and improve in a "massive" game against fellow strugglers Birmingham City tomorrow night. (Club website) Photo: George Wood