The two sides played out a Premier League classic in their opening day fixture last season, with a ding-dong battle at Anfield finishing 4-3 to the Reds, as the likes of Jack Harrison and Patrick Bamford found themselves on the score sheet for the Whites.
The Whites' game following a hectic international break, which has seen both Leeds' Patrick Bamford and Kalvin Phillips in action for England.
Discussing the latter, following last night's 1-1 draw with Poland, Three Lions boss Gareth Southgate said: “He's been excellent. The way he has taken to international football, it hasn't surprised us because what we'd seen with Leeds.
“Even in the Championship, we felt could convert into our team. We felt he could play an important role with us. To play in the enormity of the matches he did in the summer and play as well as he did is massive credit to him.
“He's a very, very good player and he's been a really important part of this - we're 16 games unbeaten [in regulation time] now and he's been a huge part of that.”
Meanwhile, down in the second tier, it's set to be a lively weekend of action, with Yorkshire sides Huddersfield Town, Hull City, Sheffield United and Barnsley all in action.
Take a look at the latest news round-up involving Yorkshire sides and more, as the build-up to the weekend's action continues:
1. Boro could go back for Burke
Middlesbrough and Blackburn Rovers both look set to renew their interest in Sheffield United forward Oliver Burke. He previously played for West Brom, who he joined for £15m from Bundesliga outfit RB Leipzig back in 2017. (Football League World)
Photo: Clive Mason
2. Ex-Blues star could seal big-money Liverpool move
Liverpool have been tipped to launch an £80m move for Borussia Dortmund midfielder Jude Bellingham next summer, as they look to revamp their midfielder. The ex-Birmingham City sensation was part of England's Euro 2020 campaign, where they finished as runners-up. (Daily Star)
Photo: Michael Regan
3. Championship stalwart finds new club
Ex-QPR, Huddersfield Town, and Nottingham Forest man Joel Lynch has ended a lengthy wait to find a new club, after joining League Two side Crawley. The 33-year-old, who began his career with Brighton, was released by Sunderland last year. (Club website)
Photo: David Rogers
4. Blades set to off Guedioura deal
Sheffield United trialist Adlene Guedioura is said to be on the brink of securing a one-year deal with the Blades, after impressing in training. He's played in England before, featuring for the likes of Watford, Crystal Palace and Wolves. (The Sun)
Photo: Matthew Lewis