Both sides head into the contest having won five of their last six league fixtures, with the Millers aiming to strengthen their position at the top of the table while the Owls are closing in on a return to the top six.
Here's all you need to know ahead of Sunday's South Yorkshire derby.
How can I watch?
The fixture is set to be broadcast by Sky Sports Football, with the game kicking off at 12pm at Hillsborough.
The match can also be streamed on Now TV, using a day pass for all Sky Sports channels which can be purchased for a one-off payment of £11.98.
Latest team news
Rotherham United have been dealt two fresh injury blows with Will Grigg and Mickel Miller picking up hamstring problems in the last week. Richard Wood is back for the visitors after serving his suspension after being sent off last weekend. Ollie Rathbone is back in contention having missed the trip to Wimbledon on Tuesday while
League One form guide
Sheffield Wednesday: WWWWLW. Rotherham United: WWWWWL.
Wednesday 2/1. Draw 23/10. Rotherham 5/4.