Ryan Hall, Mikolaj Oledzki, Andy Ackers and Joe Batchelor have all missed out from the original squad, together with the suspended John Bateman.
Wane has shown his hand by naming only two wingers in Tommy Makinson and Dom Young, whose performance in the warm-up game against Fiji saw him leapfrog Hall in the pecking order.
The backline appears to be inked in but Wane must finalise his forward options before Saturday’s curtain-raiser at St James’ Park.
Huddersfield Giants prop Chris Hill has been included in the 19-man squad but will he make the cut?
Here, The Yorkshire Post has a go at predicting Wane’s final 17 for the clash with Samoa.
5. Dom Young
The Huddersfield academy product will be one to keep an eye on after lighting up the warm-up match against Fiji. Photo: Allan McKenzie/SWpix.com
6. George Williams
Wane has pumped up the half-back's tyres throughout the year and now is the time to deliver. Photo: Allan McKenzie/SWpix.com
7. Marc Sneyd
With Salford team-mate Andy Ackers omitted from the 19, Sneyd appears nailed on to start after coming from nowhere to make the original squad. His kicking game will be key. Photo: Allan McKenzie/SWpix.com
8. Tom Burgess
One of four survivors in the squad from the 2017 World Cup final, Burgess has a huge role to play against a formidable Samoa pack. Photo: Allan McKenzie/SWpix.com