Ryan Hall, Mikolaj Oledzki, Andy Ackers and Joe Batchelor have all missed out from the original squad, together with the suspended John Bateman.
Wane has shown his hand by naming only two wingers in Tommy Makinson and Dom Young, whose performance in the warm-up game against Fiji saw him leapfrog Hall in the pecking order.
The backline appears to be inked in but Wane must finalise his forward options before Saturday’s curtain-raiser at St James’ Park.
Huddersfield Giants prop Chris Hill has been included in the 19-man squad but will he make the cut?
Here, The Yorkshire Post has a go at predicting Wane’s final 17 for the clash with Samoa.
9. Micky McIlorum
The Catalans Dragons hooker is another player Wane trusts and he will need to put in a big shift in the absence of Ackers. Photo: Allan McKenzie/SWpix.com
10. Luke Thompson
The front row will need to lay a strong platform if England are to win the opening game. Photo: Allan McKenzie/SWpix.com
11. Elliott Whitehead
Another player that has carried around the pain of 2017, Whitehead will be a key man for England. Photo: Alex Whitehead/SWpix.com
12. Mike McMeeken
The former Castleford Tigers forward has been nursing a leg injury all week but appears to be winning his fitness race. Kai Pearce-Paul is on standby. Photo: Allan McKenzie/SWpix.com