Ryan Hall, Mikolaj Oledzki, Andy Ackers and Joe Batchelor have all missed out from the original squad, together with the suspended John Bateman.
Wane has shown his hand by naming only two wingers in Tommy Makinson and Dom Young, whose performance in the warm-up game against Fiji saw him leapfrog Hall in the pecking order.
The backline appears to be inked in but Wane must finalise his forward options before Saturday’s curtain-raiser at St James’ Park.
Huddersfield Giants prop Chris Hill has been included in the 19-man squad but will he make the cut?
Here, The Yorkshire Post has a go at predicting Wane’s final 17 for the clash with Samoa.
13. Victor Radley
The Australian has pledged his allegiance to England and will not take a backwards step at St James' Park. Photo: Allan McKenzie/SWpix.com
14. Morgan Knowles
Knowles is set for a different role following the emergence of Radley but he will lead the way when he is on the field. Photo: Allan McKenzie/SWpix.com
15. Jack Welsby
Many would prefer to see the St Helens star on from the start but he is a handy option to have on the bench. Photo: Allan McKenzie/SWpix.com
16. Matty Lees
Another player fresh from winning the Super League Grand Final, Lees will be out to continue his strong club form and ensure Alex Walmsley isn't missed at international level either. Photo: Allan McKenzie/SWpix.com