Three lanes were shut at around 5pm but a police response to move vehicles has now reduced this to just one lane closure, Highways England said.
One Twitter used, named only as Leanne, posted: "Massive accident on the m62, only 1 lane open. At a complete stand still..."
It is not yet known which direction the lanes are shut in.
Highways England tweeted: "#M62 J26 to J25 #HartsheadServices multiple vehicle RTC, Lane 1,2 & 3 closure set to assist. #TrafficOfficers enroute."