A high-sided articulated truck was seen blazing away earlier on the M1 before the services at Woolley Edge.
It left a burned out shell.
Earlier it was down to one lane but a motorist told The Yorkshire Post at 10.30pm there was now a massive queue and traffic was being siphoned off the motorway at junction 38.
He said: "All the overhead signs are saying the M1 is closed at junction 38.
"There's massive delays, just crawling traffic and lots of lorries. It is total chaos."
A driver, who has just passed the scene earlier, said: "There were at least three fire engines and three or four police cars before the services.
"It was a really fierce blaze."