At tea, Lancashire are 187-1, with Haseeb Hameed on 85 and Luke Procter on 51.
Ryan Sidebottom took the only wicket to fall in the fifth over after lunch when he trapped Tom Smith lbw for 46.
Otherwise, it has been tough going for the visitors on an unresponsive pitch, with Lancashire defending solidly and taking advantage of any poor deliveries.
Hameed, the 19-year-old opener, has justified all the rave reviews he has earned this season, playing a well-controlled and sensible hand.
Unbeaten on 36 at lunch, he advanced to his half-century from 124 balls with his sixth boundary, a neat leg-side flick off Steve Patterson.
Hameed used his reach impressively when cover-driving Adil Rashid to the boundary, while Procter has given the innings impetus with nine boundaries of his own.
Yorkshire are searching for inspiration and need a good last session to claw their way back.