Bloomfield, 40, takes charge of the Hatters after Rob Edwards agreed to step down from the role last week.
He arrives at the Championship from Sky Bet League One promotion hopefuls Wycombe and will be joined by assistant Richard Thomas, first-team coach Lee Harrison and analyst Ben Cirne.
Bloomfield, who has signed a three-and-a-half-year contract, made over 500 appearances for the Chairboys as a player and returned to Adams Park as a manager in 2023 following a stint in charge of Colchester.
But who will now succeed him as manager of Wycombe, a team who are second in League One, four points clear of fourth-placed Huddersfield Town who they lost 1-0 to last Tuesday, and nine clear of Barnsley in fifth.
Here’s a look at the contenders. Odds provided by Bonus Code Bets.
5. 10. Rob Edwards - 12/1
Rob Edwards is the man who has just left his post as the Luton Town manager. He previously managed Forest Green before taking Luton into the Premier League (Picture: David Rogers/Getty Images) Photo: David Rogers
6. 9. Paul Ince - 10/1
Former Liverpool and Manchester United player Paul Ince has been out of work since leaving Reading last season (Picture: Dan Istitene/Getty Images) Photo: Dan Istitene
7. 8. Paul Lambert - 10/1
Paul Lambert during his first spell as manager of Wycombe Wanderers back in 2006, where had a successful spell before going on to manage Aston Villa, Blackburn and Wolves. (Picture: Getty Images) Photo: David Ashdown
8. 7. Dean Holden - 9/1
Former Rotherham United loanee Dean Holden has been out of management since leaving Wycombe's League One rivals Charlton in 2023. (Picture: AFP via Getty Images) Photo: OLI SCARFF